Array 2 - Intestinal Antigenic Permeability Screen

Your gut is the gateway to your overall health. When your intestinal lining is strong and intact, it acts as a protective barrier—keeping harmful substances out of your bloodstream while allowing essential nutrients to pass through. But when this lining becomes compromised, a condition commonly known as “leaky gut” can develop, leading to inflammation, immune dysregulation, and a cascade of health concerns that extend far beyond the digestive system.

The Array 2 – Intestinal Antigenic Permeability Screen by Cyrex Labs is a cutting-edge diagnostic tool designed to detect intestinal permeability with remarkable accuracy. By identifying immune responses to critical gut barrier proteins, this test provides an early warning of gut dysfunction—often before major symptoms appear.

The Array 2 test helps identify markers like zonulin and LPS—critical indicators of leaky gut syndromes and immune reactivity. It’s available alongside our other diagnostics within the broader Advanced Lab Testing page.

How This Test Works

Unlike traditional tests that may only hint at gut issues, Array 2 directly measures immune reactions to key structural proteins that maintain gut wall integrity:

• LPS (Lipopolysaccharides) – toxins from gut bacteria that can enter the bloodstream when the gut barrier is compromised

• Actomyosin – a protein complex essential for maintaining the tight junctions of the gut lining

• Occludin/Zona Occludens – key components of the tight junctions that regulate what passes through the intestinal wall

When the immune system begins reacting to these proteins, it’s a clear signal that the gut lining has been stressed, damaged, or compromised. By detecting this response, Array 2 identifies early stages of intestinal permeability, even in cases where symptoms are mild or nonspecific.

Who Should Consider the Array 2 Test?

This test is ideal for individuals who are experiencing:

• Chronic digestive symptoms such as bloating, gas, abdominal discomfort, or irregular bowel habits

• Food sensitivities or intolerances that seem to be increasing over time

• Inflammatory conditions or early signs of autoimmune disorders

• Persistent fatigue or low energy levels that don’t improve with rest

• Brain fog, difficulty concentrating, or mood changes linked to gut health

• Skin issues like eczema, rashes, or unexplained irritation that may stem from systemic inflammation

Even if you’re not currently experiencing severe symptoms, this test can be a valuable screening tool for individuals at risk due to chronic stress, poor diet, toxin exposure, or a family history of autoimmune conditions. These are not explained by standard labs. After your results are in, our Personalized Consultations offer tailored guidance based on your immune and gut permeability profile.

Why Early Detection Matters

Leaky gut doesn’t just affect digestion—it can trigger widespread inflammation, disrupt hormone balance, and strain the immune system, increasing the risk for long-term health issues. By identifying intestinal permeability early, you can:

• Take proactive steps to restore gut barrier integrity

• Reduce systemic inflammation and immune overactivation

• Support healthier digestion, nutrient absorption, and microbiome balance

• Prevent the progression of autoimmune and inflammatory conditions

With the insights gained from Array 2, you and your provider can develop a personalized care plan that addresses the root cause of gut dysfunction and supports long-term digestive and immune wellness.

The Benefits of the Array 2 Test

• Accurate detection of gut barrier damage before severe symptoms develop

• Actionable insights that guide tailored interventions

• Prevention-focused results that can help avoid downstream complications

• A clearer understanding of how gut health may be impacting your entire body

By pinpointing antigenic reactions in the gut lining, Array 2 supports precision care—often paired with other tests found in our Advanced Testing catalog.