Array 3x - Wheat/Gluten Proteome Reactivity and Autoimmunity

Gluten-related health challenges can be complex and often misunderstood. While standard gluten tests typically look for reactivity to a single marker, alpha-gliadin, they miss the broader picture of how the immune system may respond to the many other peptides found in wheat and gluten-containing foods.

The Array 3X – Wheat/Gluten Proteome Reactivity and Autoimmunity test by Cyrex Labs offers a comprehensive, cutting-edge assessment of immune reactivity to a wide range of wheat and gluten-related proteins. By evaluating dozens of peptides, including glutenin, gluteomorphin, wheat germ agglutinin, and more, this test goes far beyond conventional screening to uncover hidden sensitivities that may be driving ongoing symptoms or immune activation.

This advanced panel also evaluates immune activity linked to autoimmune processes, making it an invaluable tool for individuals seeking deeper insight into how gluten may be affecting their health—even for those already following a gluten-free lifestyle.

The Array 3X test scans dozens of wheat and gluten-derived antigens—including gliadins, glutenins, gluteomorphins, and tissue transglutaminases—to detect immune reactivity that may indicate celiac disease, non-celiac gluten sensitivity, or broader wheat-related conditions. This panel complements other tests in our Advanced Lab Testing suite for a comprehensive digestive health overview.

What Makes Array 3X Different?

Traditional testing for celiac disease and gluten sensitivity often provides only a partial view, focusing on one or two gluten markers. In contrast, Array 3X:

• Screens for multiple wheat and gluten proteins missed by standard tests

• Detects immune reactivity that may persist even after adopting a gluten-free diet

• Identifies hidden triggers of ongoing symptoms, such as gluteomorphin (a peptide linked to neurological symptoms) and wheat germ agglutinin (a lectin that can provoke immune responses)

• Assesses patterns of immune dysregulation that may contribute to autoimmune risk

This level of precision and depth helps you and your healthcare provider better understand the role of gluten in your health, guiding more effective strategies for healing and prevention.

Who Should Consider the Array 3X Test?

This test is ideal for individuals who:

• Have been diagnosed with celiac disease or non-celiac gluten sensitivity but still experience symptoms despite removing gluten from their diet

• Are dealing with digestive discomfort, bloating, or irregular bowel habits

• Struggle with fatigue, joint pain, brain fog, or mood changes that could be linked to gluten exposure

• Experience skin issues such as eczema, dermatitis, or unexplained rashes

• Suspect hidden gluten exposure may be sabotaging their health progress

• Want to better understand whether gluten plays a role in their autoimmune risk or inflammatory conditions

Even if you’ve been gluten-free for some time, lingering immune reactivity can still impact your healing process. Array 3X provides the missing information needed to close this gap.

Ideal for individuals with persistent GI symptoms or non-responsive fatigue, chronic inflammation, or neurological concerns tied to gluten sensitivity. After receiving your results, enrolling in our Gut Health & Nutrient Optimization Program helps integrate findings into a personalized treatment plan.

Why This Test Matters

Gluten sensitivity isn’t always straightforward. For some, even small amounts of hidden gluten can trigger persistent inflammation, immune activation, and symptom flares. Without identifying the specific peptides your immune system reacts to, it’s difficult to truly personalize your diet and reduce ongoing immune stress.

By pinpointing exactly which components of wheat and gluten your body responds to, this test helps you:

• Clarify dietary triggers that may be prolonging symptoms

• Reduce inflammation and immune overactivation

• Support better digestion, energy, and cognitive function

• Lower the risk of autoimmune activation driven by chronic immune stress

The Benefits of Testing

• Comprehensive analysis of wheat and gluten reactivity

• Insights into how gluten may be influencing immune function and autoimmunity

• Personalized guidance for creating a truly effective gluten-free strategy

• A clear path toward reducing symptoms and restoring balance

With this knowledge, you can make confident, informed decisions about your diet and take a meaningful step toward healing and prevention.

By identifying immune reactions to wheat proteins—often missed by standard tests—Array 3X supports a focused elimination or management strategy. Bring these insights to our Personalized Consultations to build a data-driven roadmap for restoring wellness.